Laboratory of Structural Biology of Virus-host Interactions
Piotr Gerlach joins ReMedy IRAP at the International Institute of Molecular Mechanisms and Machines (IMol) in summer 2021. During his PhD in Dr. Stephen Cusack’s group at EMBL in Grenoble, he succeeded in determining the first atomic structure of a bunyaviral polymerase. Securing an EMBO Long Term Fellowship, he joined prof. Elena Conti’s lab at Max Planck Institute of Biochemistry in Munich, where he studied the human RNA exosome using cryo-EM. Recently, dr. Gerlach has received an EMBO Installation Grant to set up his research team at IMol.
Laboratory of Structural Biology of Virus-Host Interactions
Dr. Gerlach’s lab focuses on the intracellular interactions between the host cell and infectious RNA viruses, methodologically integrating structural biology approaches with mammalian cell cultures platform. One of the major goals is to explore how RNA viruses manipulate and reprogram protein translation – the key site of the virus-host battlefront and a center of cellular stress response pathways. The knowledge delivered by the lab will allow designing innovative therapies and broad-spectrum antivirals.
Arragain B, Effantin G, Gerlach P, Reguera J, Schoehn G, Cusack S & Malet H (2020) Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes. Nat Commun 11: 3590
Lingaraju M, Schuller JM, Falk S, Gerlach P, Bonneau F, Basquin J, Benda C & Conti E (2020) To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome. Cold Spring Harb Symp Quant Biol: 040295
Gerlach P, Schuller JM, Bonneau F, Basquin J, Reichelt P, Falk S, Conti E. Distinct and evolutionary conserved structural features of the human nuclear exosome complex. eLife (2018) 7: e38686
Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S. Comparative structural and functional analysis of bunyavirus and arenavirus cap-snatching endonucleases. PLoS Pathog (2016) 12: e1005636
Reguera J, Gerlach P, Cusack S. Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases. Curr Opin Struct Biol (2016) 36: 75-84
Gerlach P, Malet H, Cusack S, Reguera J. Structural insights into bunyavirus replication and its regulation by the vRNA promoter. Cell (2015) 161: 1267-1279