„Structure-function analysis of the spliceosome”
Laboratory of RNA Biology,
Head: Magda Konarska
POSITION IN PROJECT
structural biology, molecular biology, biochemistry,
NUMBER OF JOB OFFERS
Full-time position, stipend
3 500,00 – 4 000,00 PLN net; depending on experience
POSITION STARTS ON
"Regenerative Mechanisms for Health" ReMedy
19th May 2021
We are interested in the function of the spliceosome and in its dynamic changes during splicing, and possibly in response to stress conditions. The spliceosomal catalytic center undergoes dynamic changes during the catalytic phase of splicing; these changes affect splicing catalysis, altering splicing fidelity and thus affecting alternative splicing patterns. Using recent cryo-EM information of yeast S. cerevisiae spliceosome as a model, we focus on substrate-spliceosome interactions at the catalytic center. These studies will lead to new approaches for modulating alternative splicing patterns.
YOUR FUTURE KEY RESPONSIBILITIES:
Performing experiments using biochemical, structural and molecular biology techniques (independently and in collaboration with other team members),
Participation in experimental design and data analysis,
Participation in the data preparation and writing of manuscripts,
Active participation in lab meetings, scientific seminars and conferences.
IF YOU ARE:
MSc degree (or equivalent) in molecular biology, biophysics, biochemistry or related fields of life sciences (or perspective of obtaining one),
Solid knowledge and familiarity with laboratory techniques in at least one of the following disciplines: molecular biology, biochemistry, cell biology, genetics, transcriptomics,
Very good command of English,
Motivation and passion for experimental work.
... PLEASE APPLY.
And let us present the details to you.
CV with the list of publications,
Contact details of the scientific supervisor and other referee/s if available (preferably including direct supervisor of applicant’s MSc thesis).
We will contact selected candidates only.
Project is carried out within the International Research Agendas Programme of the Foundation for Polish Science
Project: „Structure-function analysis of the spliceosome”