Agnieszka Chacinska

Group Leader

Laboratory of Structural Cell Biology

 
 

SHORT BIO

Prof. Agnieszka Chacinska is head of ReMedy IRAP and director of the International Institute of Molecular Mechanisms and Machines PAS, IMol. She received a PhD from the Institute of Biochemistry and Biophysics PAS with Prof. Magdalena Boguta and post-doctoral training with Prof. Nikolaus Pfanner, followed by a junior group leader position at the University of Freiburg, Germany. Subsequently, in 2009 she established a Laboratory of Mitochondrial Biogenesis at the International Institute of Molecular and Cell Biology in Warsaw, which In 2017 she moved to CeNT UW, and currently transfers to IMol.

She is a corresponding member of PAS, a member of EMBO and Academia Europaea.

 

RESEARCH INTERESTS

Laboratory of Mitochondrial Biogenesis

The biogenesis of mitochondria relies on efficient import, sorting, and maturation of proteins, governed by a conserved protein translocation system. The Laboratory of Mitochondrial Biogenesis explores new links between protein transport mechanisms and mitochondrial protein homeostasis, involving crosstalk between the cytosol and mitochondrial compartments. This research will shed light on complex and dynamic processes involved in the formation of functional organelles and the maintenance of cellular protein homeostasis, failures of which can lead to pathologies, such as neurodegeneration.

 

MEMBERSHIPS AND AWARDS

 

2018

  • International Award of the FEBS Theodor Bücher medal „for outstanding achievements in Biochemistry and Molecular Biology or related sciences”.

2017

2017           

  • Individual Award from the Rector of the University of Warsaw

2016                  

  • Elected Corresponding Member of the Polish Academy of Science Award from the Prime Minister of Poland for scientific achievements,

  • Elected EMBO member,

  • Laureate, together with Peter Rehling, of Nicolaus Copernicus Polish-German Research Award given jointly by the Foundation for Polish Science (FNP) and the German Research Foundation (DFG).

2015                  

  • Award from the Minister of Science and Higher Education for scientific achievements that led to the title of Professor,

  • Award from the President of Polish Academy of Science for scientific achievement.

 

2009

  • Laureate of the Welcome Programme from the Foundation for Polish Science,

  • EMBO Installation Grantee.

2008                   

  • Eugen-Graetz Prize for research, University of Freiburg.

 

2001                  

  • Long-term FEBS fellowship,

  • Award for the Ph. D. thesis, Institute of Biochemistry and Biophysics.

1997                  

  • Grant for young scientists from the Polish State Committee for Scientific Research.

 

1996                  

  • Short-term FEBS fellowship.

 

PUBLICATIONS

2021

  • Kodroń, A., Mussulini, B.H., Pilecka, I., Chacinska, A. (2021). The ubiquitin-proteasome system and its crosstalk with mitochondria as therapeutic targets in medicine. Pharmacological Research, 163:105248. doi: 10.1016/j.phrs.2020.105248.

 

2020

  • Barchiesi, A., Bazzan, V., Tolotto, V., Elancheliyan, P., Wasilewski, M., Chacinska, A., Vascotto, C. (2020). Mitochondrial Oxidative Stress Induces Rapid Intermembrane Space/Matrix Translocation of Apurinic/Apyrimidinic Endonuclease 1 Protein through TIM23 Complex. Journal of Molecular Biology, 432(24):166713. doi: 10.1016/j.jmb.2020.11.012

  • Turek, M., Piechota, M., Shanmugam, N., Niklewicz, M., Kowalski, K., Chacinska, A., Pokrzywa, W. (2020). Nutritional status and fecundity are synchronised by muscular exopheresis. bioRxiv, doi.org/10.1101/2020.06.17.157230

  • Chojnacka, K. J., Mohanraj, M., Callegari, S., Mussulini B. H. M., Elanchelyan, P., Gosk, A., Banach, T., Góral, T., Rehling, P., Serwa, R. A., Chacińska, A. (2020). Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel metazoan specific complex III assembly factor. bioRxiv, doi.org/10.1101/2020.12.09.417287

  • Mohanraj, K., Nowicka, U., Chacinska, A. (2020). Mitochondrial control of cellular protein homeostasis. Biochemical Journal, 477(16), 3033-3054.

  • Kuzniewska, B., Cysewski, D., Wasilewski, M., Sakowska, P., Milek, J., Kulinski, T. M., Winiarski, M., Kozielewicz, P., Knapska, E., Dadlez, M., Chacinska, A., Dziembowski, A., Dziembowska, M. (2020). Mitochondrial protein biogenesis in the synapse is supported by local translation. EMBO reports, 21(8), e48882.

  • Pacheu-Grau, D., Wasilewski, M., Oeljeklaus, S., Gibhardt, C. S., Aich, A., Chudenkova, M., Dennerlein, S., Deckers, M., Bogeski, J., Warscheid, B., Chacinska, A., Rehling, P. (2020). COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria. Journal of Molecular Biology, doi: 10.1016/j.jmb.2020.01.036.

2019

  • Monteuuis, G., Miścicka, A., Świrski, M., Zenad, L., Niemitalo, O., Wrobel, L., Alam J., Chacinska A., Kastaniotis AJ., Kufel J.(2019). Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins. Nucleic acids research, 47(11), 5777-5791. doi: 10.1093/nar/gkz301.

  • Samluk, L., Urbanska, M., Kisielewska, K., Mohanraj, K., Kim, M. J., Machnicka, K.,Liszewska E., Jaworski J., Chacinska A. (2019). Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress. Molecular biology of the cell, 30(15):1864-1877. doi: 10.1091/mbc.E18-10-0628.

  • Topf, U., Uszczynska-Ratajczak, B., & Chacinska, A. (2019). Mitochondrial stress-dependent regulation of cellular protein synthesis. J Cell Sci, 132(8), DOI: 10.1242/jcs226258.

  • Pereira, G. C., Allen, W. J., Watkins, D. W., Buddrus, L., Noone, D., Liu, X., Richardson, A. P., Chacińska, A. & Collinson, I. (2019). A high-resolution luminescent assay for rapid and continuous monitoring of protein translocation across biological membranes. Journal of molecular biology, 431(8), 1689-1699. doi.org: 10.1016/j.jmb.2019.03.007

  • Mohanraj, K., Wasilewski, M., Benincá, C., Cysewski, D., Poznanski, J., Sakowska, P.., Bugajska Z., Deckers M., Dennerlein S., Fernandez-Vizarra E., Rehling P., Dadlez M., Zeviani M., Chacinska A. (2019). Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7. EMBO molecular medicine, 11(5). DOI: 10.15252/emmm.201809561

 

2018

  • Schendzielorz, A. B., Bragoszewski, P., Naumenko, N., Gomkale, R., Schulz, C., Guiard, B., Chacinska A.  & Rehling, P. (2018). Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane. Nature communications, 9(1), 4028. DOI: 10.1038/s41467-018-06492-8,

  • Sokol. A.M, Uszczynska-Ratajczak B.,Collins M.M., Bazala M., Topf U., Lundegaard, P.R., Sugunan S., Guenther S., Kuenne C., Graumann J., Chan S.S.L., Stainier D.Y.R., Chacinska A. (2018). Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish. PLoS Genet 14(11): e1007743. DOI: 10.1371/journal.pgen.1007743,

  • Kowalski L., Brągoszewski P., Khmelinskii A., Glow E., Knop M., Chacinska A. (2018). Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins. BMC Biology 16:66, DOI: 10.1186/s12915-018-0536-1.

  • Samluk L., Chroscicki P., Chacinska A. (2018). Mitochondrial protein import stress and signaling. Curr. Opin. Physiol. 03, 41–48. DOI: 10.1016/j.cophys.2018.02.010,

  • Topf, U., Suppanz, I., Samluk, L., Wrobel, L., Böser, A., Sakowska, P., Knapp, B., Pietrzyk, M. K., Chacinska, A., & Warscheid, B. (2018). Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species. Nature Communications, 9(1), 324, DOI:10.1038/s41467-017-02694-8.

 

2017

  • Gold, V.A.M., Chroscicki, P., Bragoszewski, P., Chacinska, A. (2017). Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography. EMBO Reports, DOI 10.15252/embr.201744261.

  • Bragoszewski, P., Turek, M., Chacinska, A. (2017). Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system. Open Biol., 7 (4) 170007, DOI: 10.1098/rsob.170007.

  • Chacinska A. (2017). Cell biology: Sort and destroy. Nature, 543, 324-325.

  • Wasilewski, M., Chojnacka, K., Chacinska, A. (2017). Protein trafficking at the crossroads to mitochondria. Biochim Biophys Acta, 1864(1), 125-137.

 

2016

  • Wasilewski, M., Chojnacka, K., Chacinska, A. (2016). Białka mitochondrialne – import, eksport, degradacja. Postępy Biochemii, 62(2), 94-102.

  • Callegari, S., Richter, F., Chojnacka, K., Jans, D.C., Lorenzi, I., Pacheu-Grau, D., Jakobs, S., Lenz, C., Urlaub, H., Dudek, J., Chacinska, A., Rehling, P. (2016). TIM29 is a subunit of the human carrier translocase required for protein transport. FEBS Lett, 590(23), 4147-4158.

  • Wrobel, L., Sokol, A.M., Chojnacka, M., and Chacinska, A. (2016). The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly. Sci Rep., 6, 27484.

  • Topf, U., Wrobel, L., and Chacinska, A. (2016). Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis. Trends Cell Biol, 26(8), 577-86.

  • Turakhiya, U., von der Malsburg, K., Gold, V.A., Guiard, B., Chacinska, A., van der Laan, M., Ieva, R. (2016). Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential. J Mol Biol, 428, 1041-52.

 

2015

  • Wrobel, L., Topf, U., Bragoszewski, P., Wiese, S., Sztolsztener, M.E., Oeljeklaus, S., Varabyova, A., Lirski, M., Chroscicki, P., Mroczek, S., Januszewicz, E., Dziembowski, A., Koblowska, M., Warscheid, B., Chacinska, A. (2015). Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature, 524, 485-488.

  • Keatinge, M., Bui, H., Menke, A., Chen, Y.C., Sokol, A.M., Bai, Q., Ellett, F., Da Costa, M., Burke, D., Gegg, M., Trollope, L., Payne, T., McTighe, A., Mortiboys, H., de Jager, S., Nuthhall, H., Kuo, M.S., Fleming, A., Schapira, A.H., Renshaw, S.A., Highley, J.R., Chacinska, A., Panula, P., Burton, E.A., O’Neill, M.J., Bandmann, O. (2015). Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provise evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Hum Mol Genet, 24(23), 6640-52.

  • Sakowska P, Jans DC, Mohanraj K, Riedel D, Jakobs S, Chacinska A. The oxidation status of Mic19 regulates MICOS assembly. 2015. Mol Cell Biol, 35, 4222-4237.

  • Bragoszewski, P., Wasilewski, M., Sakowska, P., Gornicka, A., Böttinger, L., Qiu, J., Wiedemann, N., Chacinska, A. (2015). Retro-translocation of mitochondrial intermembrane space proteins. Proc Natl Acad Sci U S A. 112, 7713-7718.

  • Barchiesi, A., Wasilewski, M., Chacinska, A., Tell, G., Vascotto, C. (2015). Mitochondrial translocation of APE1 relies on the MIA pathway. Nucleic Acids Res. 43, 5451-5464.

  • Chojnacka, M., Gornicka, A., Oeljeklaus, S., Warscheid, B., Chacinska, A. (2015). Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System. J Biol Chem. 290, 15304-15312.

2014

  • Ieva, R., Schrempp, S.G., Opaliński, L., Wollweber, F., Höß, P., Heißwolf, A.K., Gebert, M., Zhang, Y., Guiard, B., Rospert, S., Becker, T., Chacinska, A., Pfanner, N., van der Laan, M. (2014). Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Mol Cell 56, 641-652.

  • Gornicka, A., Bragoszewski, P., Chroscicki, P., Wenz, L.S., Schulz, C., Rehling, P., Chacinska, A. (2014). A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria . Mol Biol Cell 25, 3999-4009.

  • Melin, J., Schulz, C., Wrobel, L., Bernhard, O., Chacinska, A., Jahn, O., Schmidt, B., Rehling, P. (2014). Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix. Mol Cell Biol 34, 3473-3485.

  • Sokol, A.M., Sztolsztener, M.E., Wasilewski, M., Heinz, E., Chacinska, A. (2014). Mitochondrial protein translocases for survival and wellbeing. FEBS Lett. 588, 2484-2485.

  • Pfanner, N., van der Laan, M., Amati, P., Capaldi, R.A., Caudy, A.A., Chacinska, A., Darshi, M., Deckers, M., Hoppins, S., Icho, T., Jakobs, S., Ji, J., Kozjak-Pavlovic, V., Meisinger, C., Odgren, P.R., Park, S.K., Rehling, P., Reichert, A.S., Sheikh, M.S., Taylor, S.S., Tsuchida, N., van der Bliek, A.M., van der Klei, I.J., Weissman, J.S., Westermann, B., Zha, J., Neupert, W., Nunnari, J. (2014). Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol 204, 1083-1086.

 

2013

  • Qiu, J., Wenz, L.S., Zerbes, R.M., Oeljeklaus, S., Bohnert, M., Stroud, D.A., Wirth, C., Ellenrieder, L., Thornton, N., Kutik, S., Wiese, S,, Schulze-Specking, A., Zufall, N., Chacinska, A., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N., and Becker, T. (2013). Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell 154, 596-608.

  • Varabyova, A., Topf, U., Kwiatkowska, P., Wrobel, L., Kaus-Drobek, A., and Chacinska, A. (2013). Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1. FEBS J 280, 4943-4959.

  • Bragoszewski, P., Gornicka, A., Sztolsztener, M.E., and Chacinska, A. (2013). The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins. Mol Cell Biol 33, 2136-48.

  • Wrobel, L., Trojanowska, A., Sztolsztener, M.E., and Chacinska, A. (2013). Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria.  Mol Biol Cell 24, 543-554.

  • Varabyova, A., Stojanovski, D., and Chacinska, A. (2013). Mitochondrial protein homeostasis. IUBMB Life 65, 191-201.

  • Sztolsztener, M.E., Brewinska, A., Guiard, B., and Chacinska, A. (2013). Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40. Traffic 14, 309-320.

2012

  • Böttinger, L., Gornicka, A., Czerwik, T., Bragoszewski, P., Loniewska-Lwowska, A., Schulze-Specking, A., Truscott, K.N., Guiard, B., Milenkovic, D., and Chacinska, A. (2012). In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins. Mol Biol Cell 23, 3957-3969.

  • Bohnert, M., Wenz, L.S., Zerbes, R.M., Horvath, S.E., Stroud, D.A., von der Malsburg, K., Muller, J.M., Oeljeklaus, S., Perschil, I., Warscheid, B., Chacinska, A., Veenhuis, M., van der Klei, I.J., Daum, G., Wiedemann, N., Becker, T., Pfanner, N., van der Laan, M. (2012). Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane. Mol Biol Cell 23, 3948-3956.

  • Stojanovski, D., Bragoszewski, P., and Chacinska, A. (2012). The MIA pathway: A tight bond between protein transport and oxidative folding in mitochondria. Biochim Biophys Acta 1823, 1142-1150.

2011

  • von der Malsburg, K., Müller, J.M., Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J.C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner ,N.*, Chacinska, A.*, van der Laan, M. (2011). Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Developmental Cell, 21, 694-707. (*co-corresponding author)

  • Becker, T., Wenz, L.S., Krüger, V., Lehmann, W., Müller, J.M., Goroncy, L., Zufall, N., Lithgow, T., Guiard, B., Chacinska, A., Wagner, R., Meisinger, C., Pfanner, N. (2011). The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol 194, 387-95.

  • Schulz, C., Lytovchenko, O., Melin, J., Chacinska, A., Guiard, B., Neumann, P., Ficner, R., Jahn, O., Schmidt, B., Rehling, P. (2011). Tim50’s presequence receptor domain is essential for signal driven transport across the TIM23 complex. J Cell Biol 195, 643-56.

2010

  • Chacinska, A., van der Laan, M., Mehnert, C.S., Guiard, B., Mick, D.U., Hutu, D.P., Truscott, K.N., Wiedemann, N., Meisinger, C., Pfanner, N., Rehling, P. (2010). Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol Cell Biol 30, 307-318.

  • Voegtle, F. N., Schmidt, O., Chacinska, A., Pfanner, N., Meisinger, C. (2010). Native techniques for analysis of mitochondrial protein import. Methods Mol Biol 619, 425-436.

2009

  • Chacinska, A., Koehler, C.M., Milenkovic, D., Lithgow, T., Pfanner, N. (2009). Importing mitochondrial proteins: machineries and mechanisms. Cell 138, 628-644.

  • Milenkovic, D., Ramming, T., Müller, J.M., Wenz, L.S., Gebert, N., Schulze-Specking, A., Stojanovski, D., Rospert, S., Chacinska, A. (2009). Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell 20, 2530-2539.

  • Baker, M.J., Webb, C.T., Stroud, D.A., Palmer, C.S., Frazier, A.E., Guiard, B., Chacinska, A., Gulbis, J.M., Ryan M. (2009). Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell 20, 769-779.

2008

  • Stojanovski, D., Milenkovic, D., Müller, J.M., Gabriel, K., Schulze-Specking, A., Baker, M.J., Ryan, M.T., Guiard, B., Pfanner, N.,* Chacinska, A.* (2008). Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase. J Cell Biol 183, 195-202. (*co-corresponding author)

  • Chacinska*, A., Guiard*, B., Müller, J.M., Schulze-Specking, A., Gabriel, K., Kutik S., Pfanner N. (2008). Mitochondrial biogenesis: switching the sorting pathways of the intermembrane space receptor Mia40. J Biol Chem 283, 29723-29729. (*equal contribution).

  • Müller, J.M., Milenkovic, D., Guiard, B., Pfanner, N., Chacinska, A. (2008). Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space. Mol Biol Cell 19, 226-236.

  • Hutu, D.P., Guiard, B., Chacinska, A., Becker, D., Pfanner, N., Rehling, P., van der Laan, M. (2008). Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase. Mol Biol Cell 19, 2642-2649.

  • Gebert, N., Chacinska, A., Wagner, K., Guiard, B., Koehler, C.M., Rehling, P., Pfanner, N., Wiedemann, N. (2008). Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep 9, 548-554.

  • Stojanovski, D., Müller, J.M., Milenkovic, D., Guiard, B., Pfanner, N., Chacinska, A. (2008). The MIA system for protein import into the mitochondrial intermembrane space. Biochim Biophys Acta 1783, 610-617.

2007

  • Milenkovic, D., Gabriel, K., Guiard, B., Schulze-Specking, A., Pfanner, N., Chacinska, A. (2007). Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermemembrane space receptor Mia40. J Biol Chem. 282, 22472-22480.

  • Milenkovic, D., Müller, J.M.M., Stojanovski, D., Pfanner, N., Chacinska, A. (2007). Diverse mechanisms and machineries for import of mitochondrial proteins.  Biol Chem 388, 891-897.

  • Meisinger, C., Pfannschmidt, S., Rissler, M., Milenkovic, D., Becker, t., Stojanovski, D., Youngman, M.J., Jensen, R.E., Chacinska, A., Guiard, B., Pfanner, N., Wiedemann, N. (2007). The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J 26, 2229-2239.

  • Sanjuán Szklarz, L.K., Kozjak-Pavlovic, V., Vogtle, F.N., Chacinska, A., Milenkovic, D., Vogel, S., Durr, M., Westermann, B., Guiard, B., Martinou, J.C., Borner, C., Pfanner, N., and Meisinger, C. (2007). Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins. J Mol Biol 368, 44-54.

  • Gabriel, K., Milenkovic, D., Chacinska, A., Muller, J., Guiard, b., Pfanner, N., and Meisinger, C. (2007). Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. J Mol Biol 365, 612-620.

2006

  • Wiedemann, N., Pfanner, N., and Chacinska, A. (2006). Chaperoning through the mitochondrial intermembrane space. Mol Cell 21, 145-148.

  • Meinecke, M., Wagner, R., Kovermann, P., Guiard, B., Mick, D.U., Hutu, D.P., Voos, W., Truscott, K.N., Chacinska, A., Pfanner, N., and Rehling, P. (2006). Tim50 maintains the permeability barrier of the mitochondrial inner membrane. Science 312, 1523-1526.

  • Albrecht, R., Rehling, P., Chacinska, A., Brix, J., Cadamuro, S.A., Volkmer, R., Guiard, B., Pfanner, N., Zeth, K. (2006). Tim21 binding domain connects the preprotein translocase of both mitochondrial membranes. EMBO Rep 7, 1233-1238.

  • Rospert, S., and Chacinska, A. (2006). Distinct yet linked: chaperone networks in the eukaryotic cytosol. Genome Biol 7, 208.

2005

  • Chacinska, A.*, Lind, M.*, Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling, P. (2005). Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-829 (*equal contribution).

  • Rissler, M., Wiedemann, N., Pfannschmidt, S., Gabriel, K., Guiard, B., Pfanner, N., and Chacinska, A. (2005). The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins. J Mol Biol 353, 485-492.

  • van der Laan, M.*, Chacinska, A.*, Lind, M., Perschil, I., Sickmann, A., Meyer, H.E., Guiard, B., Meisinger, C., Pfanner, N., and Rehling, P. (2005). Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol Cell Biol 25, 7449-7458 (*equal contribution).

  • Sanjuán Szklarz, L.K., Guiard, B., Rissler, M., Wiedemann, N., Kozjak, V., van der Laan, M., Lohaus, C., Marcus, K., Meyer, H.E., Chacinska, A., Pfanner, N., and Meisinger, C. (2005). Inactivation of the mitochondrial heat shock protein Zim17 leads to aggregation of matrix Hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J Mol Biol 351, 206-218.

2004

  • Chacinska, A., Pfannschmidt, S., Wiedemann, N., Kozjak, V., Sanjuán Szklarz, L.K., Schulze-Specking, A., Truscott, K.N., Guiard, B., Meisinger, C., and Pfanner, N. (2004). Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J 23, 3735-3746.

  • Chacinska, A., and Rehling, P. (2004). Moving proteins from the cytosol into mitochondria. Biochem Soc Trans 32, 774-776.

  • Meisinger, C., Rissler, M., Chacinska, A., Sanjuán Szklarz, L.K., Milenkovic, D., Kozjak, V., Schönfisch, B., Lohaus, C., Meyer, H.E., Yaffe, M.P., Guiard, B., Wiedemann, N., and Pfanner, N. (2004). The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Developmental Cell 7, 61-71.

  • Towpik, J., Chacinska, A., Ciesla, M., Ginalski, K., and Boguta, M. (2004). Mutations in yeast MRF1 gene encoding mitochondrial release factor inhibit translation on mitochondrial ribosomes. J Biol Chem 279, 14096-14103.

2003

  • Chacinska, A., Rehling, P., Guiard, B., Frazier, A.E., Schulze-Specking, A., Pfanner, N., Voos, W., and Meisinger, C. (2003). Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J 22, 5370-5381.

  • Frazier, A.E., Chacinska, A., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling, P. (2003). Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. Mol Cell Biol 23, 7818-7828.

  • Sickmann, A., Reinders, J., Wagner, Y., Joppich, C. Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., and Meisinger, C. (2003). The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci USA 100, 13207-13212.

  • Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N., and Meisinger, C. (2003). Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424, 565-571.

2002

  • Geissler, A.*, Chacinska, A.*, Truscott, K.N., Wiedemann, N., Brandner, K., Sickmann, A., Meyer, H.E., Meisinger, C., Pfanner, N., and Rehling, P. (2002). The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell 111, 507-518 (*equal contribution).

  • Chacinska, A., Pfanner, N., and Meisinger, C. (2002). How mitochondria import hydrophilic and hydrophobic proteins. Trends Cell Biol 12, 299-303.

  • Pfanner, N. and Chacinska, A. (2002). The mitochondrial import machinery: preprotein-conducting channels with binding sites for presequences. Biochim Biophys Acta 1592, 15-24.

2001

  • Chacinska, A., Szczesniak, B., Kochneva-Pervukhova, N. V., Kushnirov, V.V., Ter-Avanesyan, M.D., and Boguta, M. (2001). Ssb1 chaperone is a [PSI+] prion-curing factor. Curr Genet 39, 62-67.

2000

  • Chacinska, A., Boguta, M., Krzewska, J. and Rospert, S. (2000). Prion-dependent switching between respiratory competence and deficiency in the yeast nam9-1 mutant. Mol Cell Biol 20, 7220-9.

  • Chacinska, A., Boguta, M. (2000). Coupling of mitochondrial translation with the formation of respiratory complexes in yeast mitochondria. Acta Biochim Pol 47, 973-91.

 

1997

  • Boguta, M., Chacinska, A., Murawski, M. and Szczesniak, B. (1997). Expression of the yeast NAM9 gene coding for mitochondrial ribosomal protein. Acta Biochim Pol 44, 251-8.

1996

  • Gora, M., Chacinska, A., Rytka, J. and Labbe-Bois, R. (1996). Isolation and functional characterization of mutant ferrochelatases in Saccharomyces cerevisiae. Biochimie 78, 144-52.

 

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